Pharmaceutical compositions comprising attenuated <i>Plasmodium </i>sporozoites and glycolipid adjuvants

摘要

Disclosed herein are pharmaceutical compositions comprising Plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range Plasmodium and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.

主权项

1. A pharmaceutical composition comprising one or more species of live attenuated Plasmodium sporozoite-stage parasites, an excipient, and a glycolipid adjuvant, wherein said adjuvant is represented by the structure of formula 1; wherein R is (CH2)10Ph(p-F).