发明名称 | Cell binding peptides for diagnosis and detection | ||
摘要 | Cell binding peptides are provided for binding to cells including urothelial and thyroid follicular cells. The peptides are useful for detection and diagnosis of cancer including bladder and thyroid cancer. A device and method for using the device for capturing cells is provided, the device includes a support having attached cell binding peptide. The support can be a slide and the device can be used for detection and diagnosis of cancer including bladder and thyroid cancer. A kit is provided with instructions for capturing cells and a support with attached cell binding peptide for detection and diagnosis of bladder and thyroid cancer. | ||
申请公布号 | US9279810(B2) | 申请公布日期 | 2016.03.08 |
申请号 | US201414523295 | 申请日期 | 2014.10.24 |
申请人 | Affinergy, LLC | 发明人 | Culp William David;Darby Martyn Kerry;Juzumiene Dalia Isolda;Krajewska Magdalena;Lygina Natalia;Morrison Juhua;Nair Shrikumar Ambujakshan;Siesser William Bourchier;Wronska Danuta |
分类号 | C12Q1/24;G01N33/569;C07K7/08 | 主分类号 | C12Q1/24 |
代理机构 | NK Patent Law, PLLC | 代理人 | NK Patent Law, PLLC |
主权项 | 1. A device for capturing cells, the device comprising a support having an attached cell binding peptide for binding to and capturing cells, wherein the peptide comprises a sequence as set forth in: a. SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or SEQ ID NO: 10; b. a conservatively substituted variant having at least 70% sequence identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or SEQ ID NO: 10; or c. a variant having at least 70% sequence identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or SEQ ID NO: 10. | ||
地址 | Durham NC US |