Nitrogen-containing saturated heterocyclic compound

摘要

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]:;
wherein R1 is a cycloalkyl group and the like, R22 is an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is —O— and the like, and R3 to R6 are the same or different and a hydrogen atom and the like;

or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.

主权项

1. A compound of the formula [I]; wherein R1 is a cycloalkyl group or a non-substituted alkyl group; R22 is 3) an optionally substituted naphthylidinyl group, 5) an optionally substituted pyrazolopyridyl group, 6) an optionally substituted indolyl group, 7) an optionally substituted benzofuranyl group, 8) an optionally substituted benzothienyl group, 9) an optionally substituted quinolyl group, 10) an optionally substituted cromanyl group, 11) an optionally substituted dihydrobenzofuranyl group, 12) an optionally substituted indazolyl group, 13) an optionally substituted pyrrolopyridinyl group, 14) an optionally substituted benzoisoxazolyl group, 15) an optionally substituted xanthenyl group, 16) an optionally substituted indolinyl group, 17) an optionally substituted quinazolinyl group, 18) an optionally substituted dihydoquinazolinyl group, 19) an optionally substituted furopyridyl group, 20) an optionally substituted dihydrofuropyridyl group, 21) an optionally substituted quinoxalinyl group, 22) an optionally substituted thienopyridyl group, 23) an optionally substituted dihydopyranopyridyl group, 24) an optionally substituted dihydrobenzothienyl group, 25) an optionally substituted dihydrothienopyridyl group, or 26) an optionally substituted imidazopyridinyl group; R is a lower alkyl group; T is a carbonyl group; Z is —O—; R3, R4, R5 and R6 are the same or different, a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group; or a pharmaceutically acceptable salt thereof.