Particle composition and pharmaceutical composition using particle composition

摘要

A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2):;
wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.

主权项

1. A pharmaceutical composition comprised of a drug encapsulated in a block copolymer, including a drug carrier represented by formula (1) or formula (2) as the block copolymer: where:
R1 is a hydrogen atom, a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms or a target binding site bound to a linking group;R2 is a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms;A is a hydrophilic polymer chain;L1 and L3 are each a linking group;B is a cation-containing group;R3 is a side chain of an amino acid;z is an integer of 5 to 500;x is an integer of 40% or more of z;y is 0 or a positive integer;z-x-y is 0 or a positive integer;p is an integer of 1 to 10; andq is an integer of 1 to 10.