METHOD FOR PRODUCING BOSENTAN USING DEHYDRATING AGENT OR HYDRATE THEREOF

摘要

PROBLEM TO BE SOLVED: To produce high purity bosentan by suppressing the formation of 4-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(pyrimidine-2-yl)pyrimidine-4-yl]benzenesulfonamide which is a reaction by-product or a hydrate thereof.SOLUTION: There are produced: high purity bosentan by suppressing the formation of a reaction by-product by carrying out a reaction between 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidine-2-yl)pyrimidine-4-yl]benzenesulfonamide and ethylene glycol by adding sodium hydroxide as a base and further a dehydrating agent; and a hydrate thereof.SELECTED DRAWING: Figure 4