PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE

摘要

PROBLEM TO BE SOLVED: To provide pyrazine derivatives useful as inhibitors of ATR protein kinase, playing an important role in the DNA damage response (DDR) of a cancer cell.SOLUTION: The invention relates to pyrazine derivatives useful as inhibitors of ATR protein kinase, represented by the following formula, having the functions to stop the DNA repair processes of cancer cells and inhibit the cellular survival of cancer cells, and useful for treatment of cancer [Y is a methylene group or the like; A is a 5 membered heterocycle or the like; Q is an aromatic ring comprising 0-4 hetero atom(s) or the like; L is an alkyl chain; R, Rand Rare H, a ring comprising a hetero atom or the like; Jis CN or the like; m, p and q are 0 or 1 and the like].SELECTED DRAWING: None