MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION

摘要

Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.

主权项

1. A method of increasing high density lipoprotein (HDL) levels in a human subject, comprising (a) selecting a human subject in need of treatment of cardiovascular disease, and (b) administering to the human subject a therapeutically effective amount of a compound comprising a modified oligonucleotide 12 to 30 nucleobases in length targeted to an apolipoprotein C-III (ApoCIII) nucleic acid as shown in SEQ ID NOs:1-2, wherein after (b) HDL levels are increased and the cardiovascular disease is treated in the human subject.