CRYSTALLIZATION PROCESS OF ARIPIPRAZOLE DERIVATIVES IN EXTENDED RELEASE FORMULATIONS FOR TREATMENT OF SCHIZOPHRENIA

摘要

Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about 0.50 to about 3.3 m 2/g; and crystals of aripiprazole lauroxil produced by such processes. The present invention provides a process for making a compound of Formula (A) in crystal form wherein Ra is CH20C(O)R and wherein R1 is a substituted or unsubstituted aliphatic moiety.