发明名称 |
METHODS FOR RAPID AND SENSITIVE DETECTION OF HOTSPOT MUTATIONS |
摘要 |
Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay. |
申请公布号 |
WO2016032947(A1) |
申请公布日期 |
2016.03.03 |
申请号 |
WO2015US46519 |
申请日期 |
2015.08.24 |
申请人 |
DUKE UNIVERSITY |
发明人 |
YAN, HAI;HE, YIPING;YANG, RUI;DIPLAS, BILL H.;HANSEN, LANDON;BIGNER, DARELL |
分类号 |
C12Q1/68;C12N15/10;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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