发明名称 MACROCYCLIC THERAPEUTIC AGENTS AND METHODS OF TREATMENT
摘要 The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
申请公布号 US2016060299(A1) 申请公布日期 2016.03.03
申请号 US201514936323 申请日期 2015.11.09
申请人 University of Florida Research Foundation, Inc. 发明人 Luesch Hendrik
分类号 C07K11/02;A61K38/15;A61K45/06 主分类号 C07K11/02
代理机构 代理人
主权项 1. A compound of formula I′: wherein Each X is independently S or O; Each Y is independently H or Me; Each R is independently alkyl optionally substituted with OH, OMe, SH, SMe, optionally substituted phenyl, NH2, NH-alkyl, or N(alkyl)(alkyl); or each R is independently the side chain of a naturally-occurring or non-natural amino acid (including, e.g., phenylalanine, tyrosine, tryptophan, histidine, serine, methionine, and the like); or wherein each Y and R and the adjacent atoms attached to them (nitrogen and carbon, respectively) can combine to form a heterocyclic ring; Each R2 is independently H, alkyl, or —C(O)alkyl.
地址 Gainesville FL US