COSTIMULATION OF CHIMERIC ANTIGEN RECEPTORS BY MYD88 AND CD40 POLYPEPTIDES

摘要

The technology relates generally to the field of immunology and relates in part to methods for activating T cells and other cells resulting in an immune response against a target antigen. The technology also relates to costimulation of therapeutic cells that express chimeric antigen receptors that recognize target antigens using chimeric MyD88- and CD40-derived polypeptides. The technology further relates in part to therapeutic cells that express chimeric antigen receptors, wherein the chimeric antigen receptors have an endodomain that includes MyD88- and CD40-derived polypeptides, and methods for treating patients using the modified therapeutic cells.

主权项

1. A nucleic acid comprising a promoter operably linked to a polynucleotide encoding a chimeric stimulating molecule, wherein the chimeric stimulating molecule comprises
(i) a MyD88 polypeptide or a truncated MyD88 polypeptide lacking the TIR domain; (ii) a CD40 cytoplasmic polypeptide region lacking the CD40 extracellular domain; and (iii) a membrane targeting region.