发明名称 |
METHOD FOR THE PRODUCTION OF 18F-LABELED ACTIVE ESTERS AND THEIR APPLICATION EXEMPLIFIED BY THE PREPARATION OF A PSMA-SPECIFIC PET-TRACER |
摘要 |
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18F- are described. The active ester including [18F]F-Py-TFP and [18F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [18F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor. |
申请公布号 |
WO2016030329(A1) |
申请公布日期 |
2016.03.03 |
申请号 |
WO2015EP69356 |
申请日期 |
2015.08.24 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
NEUMAIER, BERND;ZLATOPOLSKIY, BORIS;RICHARZ, RAPHAEL;KRAPF, PHILLIP |
分类号 |
C07D213/81;A61K31/44;A61P35/00;C07C231/02;C07C275/16;C07D213/82;C07D231/14;C07D241/24 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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地址 |
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