METHOD FOR DETECTING ABNORMALITIES IN HEMOGLOBIN

摘要

The method describes rapid screening of whole blood samples, pin prick and blood spot cards, subjected to MALDI – ToF Mass spectrometry. The spectra is generated and compared to those from normal healthy controls. Characteristic spectra are indicative of the presence of a hemoglobinopathy and the method can be used to screen/diagnose all sickle cell diseases, alpha and beta Thalassemias.