发明名称 |
NOVEL CHROMONE OXIME DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS |
摘要 |
The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and, furthermore, presents an advantageously high brain penetration upon oral administration. The invention also relates to a pharmaceutical composition containing this compound, and to its use for the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions, or conditions which can be affected by alteration of glutamate level or signalling, particularly acute and chronic neurological and/or psychiatric disorders. |
申请公布号 |
WO2016030444(A1) |
申请公布日期 |
2016.03.03 |
申请号 |
WO2015EP69601 |
申请日期 |
2015.08.27 |
申请人 |
PREXTON THERAPEUTICS SA |
发明人 |
CHARVIN, DELPHINE;MANTEAU, BAPTISTE;POMEL, VINCENT;CONQUET, FRANÇOIS |
分类号 |
C07D495/04;A61K31/407;A61P25/16 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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