COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS

摘要

Oligonucleotide conjugates including sequence independent oligonucleotide conjugates having at least one subunit of formula (I) as well as chelates of oligonucleotide conjugates are disclosed. Methods of using such oligonucleotide conjugates and oligonucleotide conjugate chelates for the treatment of viral infections, including HBV infections or HBV/HDV co-infections are also disclosed, the method comprising administering to a subject in need of treatment a first pharmaceutically acceptable agent that is an oligonucleotide conjugate or chelate thereof and an optional second pharmaceutically acceptable agent which stimulates immune function and an 10 optional third pharmaceutically acceptable agent comprising an antiviral compound.