| 发明名称 |
METHOD FOR INCREASING PYRO-GLUTAMIC ACID FORMATION OF A PROTEIN |
| 摘要 |
A method for conversion of an N-terminal glutamine and/or glutamic acid residue of a protein to pyro-glutamic acid within a purification process. |
| 申请公布号 |
US2016060349(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201414780964 |
申请日期 |
2014.04.03 |
| 申请人 |
MABXIENCE S.A. |
发明人 |
VAN SCHRAVENDIJK Marie Rose;WAUGH Stephen;THORNE Barbara |
| 分类号 |
C07K16/28;C07K1/34;C07K1/18 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for purification of a protein containing an N-terminal glutamine and/or an N-terminal glutamic acid, the method comprising a step of incubating said protein under conditions to promote cyclization of the N-terminal glutamine and/or an N-terminal glutamic acid of said protein to N-terminal pyro-glutamic acid. |
| 地址 |
Montevideo UY |
