| 发明名称 |
DOT1L Inhibitors |
| 摘要 |
Provided herein are inhibitors of DOT1L useful for treating diseases or disorders associated with DOT1L. An exemplary DOT1L inhibitor provided herein exhibits a biological half-life of 12.6 h. Methods for treating diseases associated with DOT1L are also provided. |
| 申请公布号 |
US2016060269(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201514838142 |
申请日期 |
2015.08.27 |
| 申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
Bradner James E.;Qi Jun;Federation Alexander |
| 分类号 |
C07D487/04 |
主分类号 |
C07D487/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of CN, halo, and C1-4 haloalkyl. |
| 地址 |
Boston MA US |
