BROMODOMAIN INHIBITORS FOR TREATING DISEASE

摘要

Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I:;;Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.

主权项

1. A compound of structural Formula I or a salt thereof, wherein: m is chosen from the integers 0, 1, 2, and 3; X is chosen from alkyl, aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl; each R1 is independently chosen from alkenyl, alkyl, H, and haloalkyl; each R2 is independently chosen from alkenyl, alkoxy, alkyl, aryl, arylalkyl, cyano, cycloalkyl, H, halo, haloalkoxy, heteroaryl, heteroarylalkyl, heterocycloalkyl, hydroxyl, N(R3)2, C(O)OH, N(R3)C(O)C(R3)3, N(R3)C(O)OC(R3)3, C(O)OC(R3)3, and C(O)N(R3)2, wherein two R2 groups together with the atoms to which they are attached optionally form an aryl, cycloalkyl, heteroaryl, or heterocycloalkyl ring, which may be optionally substituted with between 0 and 3 R3 groups; each R3 is independently chosen from alkenyl, alkoxy, alkyl, aminoalkyl, aryl, arylalkyl, cyano, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, H, halo, haloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, and hydroxyl; and G is phenyl, which may be optionally substituted.