QUINOLYL AMINES AS KINASE INHIBITORS

摘要

Disclosed are compounds having the formula:;wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.

主权项

1. A compound according to Formula (I): wherein: R1 is H, —SO2(C1-C4)alkyl, —CO(C1-C4)alkyl, or (C1-C4)alkyl; R2 is —SRa, —SORa, or —SO2Ra, wherein Ra is (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C7)cycloalkyl, 4-7 membered heterocycloalkyl, aryl, or heteroaryl, wherein: said (C1-C6)alkyl is optionally substituted by one or two groups each independently selected from cyano, hydroxyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C2-C6)alkoxy, —CO2H, —CO2(C1-C4)alkyl, —SO2(C1-C4)alkyl, (C3-C7)cycloalkyl, phenyl, 5-6 membered heteroaryl, 9-10 membered heteroaryl, 4-7 membered heterocycloalkyl and (phenyl)(C1-C4 alkyl)amino-, wherein said (C3-C7)cycloalkyl, phenyl, (phenyl)(C1-C4 alkyl)amino-, 5-6 membered heteroaryl, 9-10 membered heteroaryl or 4-7 membered heterocycloalkyl is optionally substituted by 1-3 groups each independently selected from halogen, —CF3, hydroxyl, amino, ((C1-C4)alkyl)amino-, ((C1-C4)alkyl)((C1-C4)alkyl)amino-, (C1-C4)alkyl, phenyl(C1-C4)alkyl-, hydroxy(C1-C4)alkyl and (C1-C4)alkoxy, said (C3-C7)cycloalkyl or 4-7 membered heterocycloalkyl is optionally substituted by 1-3 groups each independently selected from halogen, —CF3, hydroxyl, amino, ((C1-C4)alkyl)amino-, ((C1-C4)alkyl)((C1-C4)alkyl)amino-, (C1-C4)alkyl, phenyl(C1-C4)alkyl-, hydroxy(C1-C4)alkyl-, oxo and (C1-C4)alkoxy, and said aryl or heteroaryl is optionally substituted by 1-3 groups each independently selected from halogen, —CF3, hydroxyl, amino, ((C1-C4)alkyl)amino-, ((C1-C4)alkyl)((C1-C4)alkyl)amino-, (C1-C4)alkyl, phenyl(C1-C4)alkyl-, hydroxy(C1-C4)alkyl- and (C1-C4)alkoxy; R3 is methyl, hydroxymethyl, trifluoromethyl, carboxy, or —CO2(C1-C4)alkyl; R4 is H, methyl, hydroxymethyl, trifluoromethyl, carboxy, or —CO2(C1-C4)alkyl; R5 is H or (C1-C3)alkyl; or a salt thereof, or hydrate thereof.