| 发明名称 |
LOW VISCOSITY CONCENTRATED PROTEIN DISPERSIONS |
| 摘要 |
Disclosed herein are, inter alia, low viscosity dispersions comprising proteins and viscosity lowering agents; pharmaceutical compositions comprising low viscosity dispersions; and methods of making and using the pharmaceutical compositions and low viscosity dispersions. |
| 申请公布号 |
US2016058863(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201514843897 |
申请日期 |
2015.09.02 |
| 申请人 |
Board of Regents, The University of Texas System |
发明人 |
Johnston Keith P.;Truskett Thomas;Dear Barton;Dinin Aileen;Borwankar Ameya;Hung Jessica |
| 分类号 |
A61K47/18;A61K47/22;A61K47/26;A61K39/395 |
主分类号 |
A61K47/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A low viscosity dispersion comprising a protein and a viscosity lowering agent selected from the group consisting of proline, histidine, lysine, arginine, glutamic acid, betaine, glutamine, asparagine, imidazole, and a combination of two or more thereof; wherein
the viscosity lowering agent is present at a concentration from about 10 mg/mL to about 400 mg/mL; the protein is present at a concentration greater than 200 mg/mL and within a plurality of protein nanoclusters; and the viscosity is about 1 cP to about 125 cP. |
| 地址 |
Austin TX US |
