| 发明名称 |
MULTI-STEP METHOD FOR FABRICATING TISSUE ENGINEERING BONE |
| 摘要 |
A multi-step method for fabricating a tissue engineering bone comprises the following steps: (1) scaffold repair and pre-vascularization: fabricating a tissue engineering bone scaffold at a bone defect site, and conducting pre-vascularization; and (2) post-implantation of a seed cell for bone tissue engineering: after an inflammatory reaction period, combined with time for micro-vessel in-growth, implanting an osteogenic-induced seed cell into a tissue engineering bone scaffold at the bone defect site. In certain embodiments, the step (2) of post-implantation of a seed cell for bone tissue engineering is performed 7 to 14 days after the step (1) of scaffold repair and pre-vascularization. The method can be used to rapidly fabricate a large section of tissue engineering bone, greatly reduce usage of the seed cell for bone tissue engineering required in repair of per unit volume of bone tissue, and improve the utilization rate of the seed cell. |
| 申请公布号 |
US2016058911(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201514935371 |
申请日期 |
2015.11.06 |
| 申请人 |
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine |
发明人 |
Zhang Zhiyong;Wang Zhenxing;Wu Dingyu;Zhang Zhanzhao |
| 分类号 |
A61L27/38;A61L27/46;A61L27/56;A61L27/36;A61L27/20 |
主分类号 |
A61L27/38 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A multi-step method for fabricating a tissue engineering bone, comprising:
(1) scaffold repair and pre-vascularization: fabricating a tissue engineering bone scaffold at a bone defect site, and conducting pre-vascularization; and (2) post-implantation of a seed cell for bone tissue engineering: implanting an osteogenic-induced seed cell into a tissue engineering bone scaffold at the bone defect site; wherein the step (2) of post-implantation of a seed cell for bone tissue engineering is performed 7 to 14 days after the step (1) of scaffold repair and pre-vascularization. |
| 地址 |
Shanghai CN |
