MICROBIOTA RESTORATION THERAPY (MRT), COMPOSITIONS AND METHODS OF MANUFACTURE

摘要

Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

主权项

1. A method for treating ulcerative colitis, the method comprising:
administering a microbiota restoration therapy composition to a patient with ulcerative colitis; wherein the microbiota restoration therapy composition is pre-screened for bacterial diversity; wherein the pre-screened microbiota restoration therapy composition includes bacteria from at least seven different families and has a Shannon Diversity Index of 0.4-2.5 when calculated at the family level; and wherein the microbiota restoration therapy composition comprises a mixture of an effective amount of fecal microbiota and an effective amount of polyethylene glycol.