TROPHIC HORMONE FUSION PROTEIN, PREPARATION METHOD AND APPLICATION THEREOF

摘要

Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof. β-subunit of the gonadotropin or thyroid stimulating hormone is fused to an Fc fragment directly or indirectly through a linker, and α-subunit binds to the β-subunit via an affinity between the α-subunit and the β-subunit. The fusion protein has a prolonged half-life and less fluctuating activity.

主权项

1. A fusion protein comprising a trophic hormone protein and an Fc fragment of an antibody, wherein β-subunit of the trophic hormone protein is linked to the Fc fragment directly or indirectly via a linker, and α-subunit of the trophic hormone protein binds to the β-subunit via intermolecular interactions between the α-subunit and the β-subunit, and wherein the trophic hormone is selected from the group consisting of luteotropic hormone, follicle stimulating hormone, chorionic gonadotropin and thyroid stimulating hormone, preferably follicle stimulating hormone.