| 摘要 |
PURPOSE:To obtain the titled compound having hypotensive action based on angiotensin converting enzyme, by reacting a specific compound with a diphenyl phosphorochloridate and a specific compound. CONSTITUTION:(A) A compound [e.g. t-butyl N-(indan-2-yl)glycinate] shown by formula I (R<1> is lower alkyl or aralkyl) is reacted with (B) a diphenyl phosphorochloridate shown by formula I (X and Y are H, lower, alkyl, lower alkoxy or halogen) and a compound {e.g. N-[(S)-1-ethoxycarbonyl-3- phenylpropyl]-L-alanine} shown by formula III (R<2> is lower alkyl; R<3> is aralkyl; R<4> is lower alkyl) to give the aimed compound {e.g. t-butyl N-[N-[(S)-1- ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycinate}. |
