发明名称 |
METHOD FOR PREPARING A VACCINE ANTIGEN, RESULTING VACCINE ANTIGEN AND USES |
摘要 |
The present invention relates to a method for preparing a vaccine antigen, which includes a step of fragmenting a biological membrane associated with said vaccine antigen by treating said biological membrane with at least one calixarene of formula (II): wherein: X is a -(CH2)-CO2Y group and Y is an alkaline metal or one of the pharmaceutically acceptable salts thereof, wherein said resulting vaccine antigen also includes a fragment of the biological membrane associated with said antigen. The present invention also relates to a vaccine that can be produced by implementing the method, including a calixarene of formula (II) in carrier format, with a quantity of 0.1 to 1,000 μg in the total weight of the vaccine. The present invention further relates to the use of a calixarene as defined above for the preparation of a vaccine or a vaccine antigen, and to the vaccine for use as a drug in the treatment or prevention of an infectious disease. |
申请公布号 |
WO2016030635(A1) |
申请公布日期 |
2016.03.03 |
申请号 |
WO2015FR52285 |
申请日期 |
2015.08.28 |
申请人 |
CALIXAR;UNIVERSITÉ CLAUDE BERNARD LYON 1;HOSPICES CIVILS DE LYON;INSERM |
发明人 |
ROSA-CALATRAVA, MANUEL;TRAVERSIER, AURÉLIEN;DESUZINGES-MANDON, ÉLODIE;DEJEAN, EMMANUEL |
分类号 |
C07K14/11;A61K39/145;C07C39/17 |
主分类号 |
C07K14/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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