MODIFIED TGF-BETA2 OLIGONUCLEOTIDES

摘要

The invention refers to an oligonucleotide consisting of 10 to 18 nucleotides of selected regions of the TGF-beta2 nucleic acid sequence, which comprises modified nucleotides such as LNA, ENA, polyalkylene oxide-, 2′-fluoro, 2′-O-methoxy and/or 2′-O-methyl modified nucleotides. The invention further relates to pharmaceutical compositions comprising such oligonuc-leotide, wherein the composition or the oligonucleotide is used in the prevention and/or treatment of a malignant and/or benign tumor, an immunologic disease, fibrosis, or an ophthalmic disease such as dry eye, glaucoma or posterior capsular opacification (PCO).

主权项

1. An antisense oligonucleotide consisting of 10 to 18 nucleotides of the TGF-beta2 nucleic acid sequence of SEQ ID NO. 1, wherein one or more nucleotide(s) of the oligonucleotide is/are modified, and wherein the modified nucleotide is a LNA, and/or an ENA, polyalkylene oxide-, 2′-fluoro-, 2′-O-methoxy-, and/or 2′0-methyl-modified nucleotide.