SYSTEM AND METHOD FOR ROBUST INTENSITY-MODULATED PROTON THERAPY PLANNING

摘要

The present invention provides a system and method for generating intensity modulated proton therapy plans. The method includes receiving a representation of a subject that includes information related to target and non-target volumes of interest, and computing, using the representation and a proton beam configuration that describes a number of beamlets and their respective arrangement, a dose distribution for each one of a plurality of uncertainty scenarios. The method also includes computing a robustness index for respective locations in the target volumes of interest using the dose distributions, and optimizing an objective function to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of the robustness indices from a prescribed robustness index. The method further includes generating a treatment plan using the determined intensity weights.

主权项

1. A computer-implemented method for generating an intensity modulated proton therapy plan, the steps of the method comprising:
(a) providing a representation of a subject that includes information related to target and non-target volumes of interest to a treatment planning system; (b) providing to the treatment planning system, a proton beam configuration that describes a number of beamlets and their respective arrangement; (c) computing with the treatment planning system, a dose distribution for each one of a plurality of uncertainty scenarios, wherein the dose distribution is computed based on the provided representation of the subject and the provided proton beam configuration; (d) computing with the treatment planning system, a robustness index for respective locations in the target volumes of interest using the computed dose distributions; (e) optimizing an objective function with the treatment planning system to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of each computed robustness index from a prescribed robustness index; and (f) generating a treatment plan with the treatment planning system using the intensity weights determined by optimizing the objective function.