| 发明名称 |
Process for preparing a composition of pegylated proteins |
| 摘要 |
This invention is in the field of protein pegylation. In particular, it relates to a method for pegylating therapeutic proteins. The invention also relates to the use of such pegylated therapeutic polypeptides for treating muscle diseases and disorders. |
| 申请公布号 |
US2016058878(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201414567430 |
申请日期 |
2014.12.11 |
| 申请人 |
JEVSEVAR Simona;KUNSTELJ Menci;PODOBNIK Barbara |
发明人 |
JEVSEVAR Simona;KUNSTELJ Menci;PODOBNIK Barbara |
| 分类号 |
A61K47/48;A61K38/18 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparing a composition of a pegylated therapeutic protein, wherein in said composition at least 61 percent of the mono pegylated therapeutic protein fraction comprised in said composition is N-terminally mono-pegylated therapeutic protein, comprising the step of:
reacting in an aqueous medium a therapeutic protein with a water-soluble polyethylene glycol under conditions of a reductive alkylation, characterized in that the reaction is performed within a pH range of about 6.5 to 7.5, to provide the composition of the pegylated therapeutic protein. |
| 地址 |
Ljubljana SI |
