ANTI-TUMOR COMPOSITIONS AND METHODS

摘要

Disclosed herein are oligonucleotide sequences that generate innate immunity in cells within tumors upon its delivery into tumors. In certain embodiments, these oligonucleotides are specifically delivered into tumors through nanoparticles displaying targeting peptides that confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.

主权项

1. A composition for targeting and inhibiting tumor cell growth comprising:
an isolated oligonucleotide capable of activating an innate immune response within tumors; a tumor cell-targeting moiety; and a pharmaceutically acceptable salt thereof.