GENE VECTOR

摘要

PROBLEM TO BE SOLVED: To provide a novel gene vector for use in gene transfer and gene therapy.SOLUTION: A gene vector for use in gene therapy comprises at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.SELECTED DRAWING: Figure 1