T-CELL-SPECIFIC HUMANIZED SINGLE FRAGMENT ANTIBODY DELIVERY VEHICLE

摘要

The present invention relates to a humanized scFv delivery vehicle targeted to be human T-cell specific, and provides: a humanized scFv which comprises a heavy-chain variable region (VH) consisting of a polypeptide comprising an amino acid sequence given by sequence number 32 and comprises a light-chain variable region (VL) consisting of a polypeptide comprising an amino acid sequence given by sequence number 34; and a T-cell-specific drug or marker delivery vehicle comprising the humanized scFv. The humanized scFv of the present invention has minimalised antigenicity and has an effect which does not give rise to an immune reaction even when used in the human body, and thus can advantageously be used as a delivery vehicle for specifically delivering a target substance such as a siRNA gene or an immune reaction regulating protein to T-cells.

主权项

1. A heavy chain variable region (VH) of a T cell-specific humanized antibody, the heavy chain variable region being composed of a polypeptide including an amino acid sequence represented by SEQ ID NO: 32.