Treatment of Operable High-Grade Glioma With Sitimagene Ceradenovec Gene Therapy and Ganciclovir

摘要

Gene therapy with genes for prodrug converting enzymes adds to local control of glioblastoma achieved by surgery. There appears to be a pronounced local reaction which is in part inflammatory and has a measurable immunological component. Considering the widely proven fact that during the weekslong gap-phase between surgery and completion of radiation or chemoradiation tumour growth from the infiltrative zone may continue unhampered, a treatment such as SIT will cover that time period.

主权项

1. In a method of treating glioblastoma in a human by surgical resection and temozolomide, an improvement comprising:
b. administering locally about the surgical resection site after surgical resection, about 1×1012 particles of replication-deficient adenovirus serotype 5 with E1 and partial E3 deletions, and containing the cDNA for HSV-tk which is able to phosphorylate ganciclovir, then c. administering gancyclovir 5 mg/kg i.v., twice daily.