| 发明名称 |
PLATFORM FOR TARGETED DELIVERY TO STEM CELLS AND TUMOR CELLS AND USES THEREOF |
| 摘要 |
The invention involves therapy and diagnostics using nanoparticles that provide targeted delivery of agents to cancer cells and stem cells, including cancer stem cells, the nanoparticles being pH sensitive and incorporating cytotoxic ceramides. |
| 申请公布号 |
US2016058886(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201414784247 |
申请日期 |
2014.04.11 |
| 申请人 |
UNIVERSIDADE DE COIMBRA |
发明人 |
Fonseca Nuno Andre Carvalho da;Silva Lígia Catarina Gomes Da;Moura Vera Lúcia Dantas Nunes Caldeira De;Simões Ségio Paulo De Magalhães;Moreira João Nuno Sereno De Almeida |
| 分类号 |
A61K47/48;A61K9/00;A61K31/164;A61K31/704;A61K31/133 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A ligand-targeted delivery system comprising,
a targeting ligand that binds a tumor cell linked to a support carrying an agent, wherein said support is a pH sensitive liposome having a cytotoxic ceramide analog encapsulated, entrapped or intercalated in the support, wherein the agent is doxorubicin encapsulated in the support, wherein the molar ratio of cytotoxic ceramide analog to doxorubicin is between (i) 40:1 and 1:5 or (ii) 3:1 and 1:2, and wherein said liposome is capable of the pH dependent intracellular release of said cytotoxic ceramide analog and said agent. |
| 地址 |
Coimbra PT |
