| 发明名称 |
HER1-TARGETED CHIMERIC ANTIGEN RECEPTOR AND NKT CELL AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF |
| 摘要 |
Provided are a chimeric antigen receptor as well as a gene and a recombinant expression vector thereof and an engineered HER1-targeted NKT cell. The chimeric antigen receptor is HER1ScFv-CD8-CD137-CD3ζ, which is composed of HER1ScFv, a hinge region and a transmembrane region of CD8, an intracellular signal structural domain of CD137 and an intracellular signal structural domain of CD3ζ connected in series, and can be used to kill lung cancer cells. |
| 申请公布号 |
WO2016029855(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
WO2015CN88172 |
申请日期 |
2015.08.26 |
| 申请人 |
CELLULAR BIOMEDICINE GROUP (SHANGHAI) LTD.;CELLULAR BIOMEDICINE GROUP (WUXI) LTD. |
发明人 |
HAN, WEIDONG;HAN, QINGWANG;WANG, XIAOHUI;GUO, YELEI;FENG, KAICHAO;FU, XIAOBING |
| 分类号 |
C07K19/00;A61K35/12;A61P35/00;C12N5/10;C12N15/62;C12N15/867 |
主分类号 |
C07K19/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
