发明名称 |
MACROLIDE COMPOUNDS AND THEIR USE IN LIVER STAGE MALARIA AND RELATED DISEASE |
摘要 |
A novel quantum-based computational process for drug discovery and design was used to identify potential novel liver-stage anti-malarial therapeutic molecules. The approach combined the latest big-data advances in high-throughput bioassay development with fundamental scientific knowledge to generate new pharmaceutical leads. Several molecules with no previous association with anti-parasitical activity were identified. These molecules and there use in prevention and/or treatment of Plasmodium infections are provided. |
申请公布号 |
CA2959331(A1) |
申请公布日期 |
2016.03.03 |
申请号 |
CA20152959331 |
申请日期 |
2015.08.25 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;GRADIENT BIOMODELING, LLC |
发明人 |
SULLIVAN, DAVID;KALUDOV, NICK;LIU, YI;MARTINOV, MARTIN |
分类号 |
C07D498/04;A61K31/424;A61K31/4725;A61K31/5377;C07D211/54;C07D249/08;C07D401/14;C07D413/14 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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