The present invention describes a mutant type II beta-lactam acylase that is a variant of a model polypeptide with type II beta-lactam acylase activity whereby the mutant beta-lactam acylase has an at least 1.5-fold improved in vitro beta-lactam acylase activity towards adipyl-7-ADCA in comparison with the model polypeptide with beta-lactam acylase activity.
申请公布号
EP2851423(B1)
申请公布日期
2016.03.02
申请号
EP20140173437
申请日期
2006.12.28
申请人
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
发明人
VAN DER LAAN, JAN METSKE;KERKMAN, RICHARD;BIJLEVELD, WILLEM;GIELESEN, BIANCA ELISABETH MARIA