发明名称 DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS
摘要 The present invention concerns a compound of following formula (I) where: —R1 is H or OH, —R2 is a (C1-C6)alkyl, COOH, COO—((C1-C6)alkyl) or thiazolyl group, —R3 is H or a (C1-C6)alkyl group, and —R4 is an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.
申请公布号 EP2989087(A1) 申请公布日期 2016.03.02
申请号 EP20140719330 申请日期 2014.04.25
申请人 PIERRE FABRE MÉDICAMENT 发明人 PEREZ, MICHEL;RILATT, IAN;LAMOTHE, MARIE
分类号 C07D401/12;A61K31/401;A61K31/4025;A61K31/427;A61K31/4439;A61K38/07;A61K38/40;A61P35/00;C07D207/08;C07D417/12;C07D417/14;C07K5/02 主分类号 C07D401/12
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