Among other aspects, provided herein is a hydrohalide salt of a multi-arm water- soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
申请公布号
MX337393(B)
申请公布日期
2016.03.02
申请号
MX20120005795
申请日期
2010.11.18
申请人
NEKTAR THERAPEUTICS
发明人
BRAY, BRIAN;KOZLOWSKI, ANTONI;CHONG, ANTHONY O.;LEE, SEOJU;JOSHI, BHALCHANDRA V.;NIE, SHAOYONG;SPENCE, PATRICK;MCMANUS, SAMUEL;TIPNIS, SACHIN;LAVATY, GREG;SWALLOW, DAVID