| 摘要 |
An optical device for determining blood glucose concentration includes an excitation light source that emits an excitation light signal; a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration. The device also includes a light sensitive module operably coupled to at least the fiber optic sensor, wherein the light sensitive module detects the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source. The fluorophore is excited by the excitation light signal and emits at least a first emission light signal and a second emission light signal, wherein the first and second emission light signals are related to glucose concentrations, and wherein a ratio of the first and second emission light signals is glucose insensitive and sensitive to pH. The fluorophore is typically a fluorescent organic dye, and the glucose binding moiety a boronic acid functionalized viologen. |
