发明名称 |
SYNTHETIC LIBRARY OF SPECIFIC BINDING MOLECULES |
摘要 |
The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine. |
申请公布号 |
EP2989203(A2) |
申请公布日期 |
2016.03.02 |
申请号 |
EP20140718999 |
申请日期 |
2014.04.23 |
申请人 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN |
发明人 |
BARELLE, CAROLINE JANE;FINLAY, WILLIAM JAMES JONATHAN;DARMANIN-SHEEHAN, ALFREDO;PORTER, ANDREW JUSTIN RADCLIFFE |
分类号 |
C12N15/13;C07K16/00;C07K16/18 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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