发明名称 |
SELECTIVE DRUG DELIVERY COMPOSITIONS AND METHODS OF USE |
摘要 |
Described herein are methods and compositions for intracellular delivery of therapeutic molecules. Disclosed herein are selective delivery conjugate comprising a targeting ligand conjugated to a selective delivery molecule (a) an acidic sequence (portion of A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion of B), and (c) a linker between portion of A and portion of B, and (d) at least one cargo moiety. Also, described are selective delivery molecules comprising a second linker comprising an intracellular cleavage site and optionally a self-immolative cleavage site. |
申请公布号 |
EP2988786(A1) |
申请公布日期 |
2016.03.02 |
申请号 |
EP20140788083 |
申请日期 |
2014.04.22 |
申请人 |
AVELAS BIOSCIENCES, INC. |
发明人 |
GONZALEZ, JESUS;LIU, JUNJIE;MIAMPAMBA,MARCEL |
分类号 |
A61K47/48;A61K31/573;A61K31/70;A61K31/704;A61K31/7042;A61K47/30;A61P29/00;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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