| 发明名称 |
PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF |
| 摘要 |
The present invention provides a compound of formula I: wherein R1, R2, R2′ and X− are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration. |
| 申请公布号 |
EP2137191(B1) |
申请公布日期 |
2016.03.02 |
| 申请号 |
EP20080742363 |
申请日期 |
2008.03.28 |
| 申请人 |
PROGENICS PHARMACEUTICALS, INC.;WYETH LLC (FORMERLY KNOWN AS WYETH) |
发明人 |
AVEY, ALFRED, A.;PEREZ, JULIO;DOSHAN, HAROLD, D.;CHANDRASEKARAN, APPAVU;ROTSHTEYN, YAKOV |
| 分类号 |
C07D489/04;A61K31/439;A61P43/00 |
主分类号 |
C07D489/04 |
| 代理机构 |
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