发明名称 |
MODIFIED HYDROGELS |
摘要 |
The present invention relates to a process for the preparation of a hydrogel suitable as carrier in a hydrogel-linked prodrug, to hydrogels obtainable from said process, the use of such hydrogel as a carrier in a hydrogel-linked prodrug and to hydrogel-linked prodrugs comprising a covalently conjugated hydrogel of the present invention. The hydrogel prodrug carrier has a reduced drug loading on the outside of the hydrogel carrier. This is achieved by reducing the number of functional groups of the hydrogel, in particular those at its surface. |
申请公布号 |
EP2988732(A1) |
申请公布日期 |
2016.03.02 |
申请号 |
EP20140721238 |
申请日期 |
2014.04.16 |
申请人 |
ASCENDIS PHARMA A/S |
发明人 |
HERSEL, Ulrich;RAU, Harald;LAUFER, Burkhardt;ZETTLER, Joachim;REIMANN, Romy |
分类号 |
A61K9/10;A61K38/20;A61K38/28;A61K47/10;A61K47/48;C08G83/00;C08J3/075 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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