| 摘要 |
The present invention describes the obtaining process of the dichloromethane fraction and subfractions from Eleutherine plicata, popularly known as "marupazinho, maruparí, palmeirinha, coquinho, marupaí, marupaú, marupá-piranga, and lírio-folha-de-palmeira". This invention comprises the obtaining process of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as its use for malaria treatment. Extract and fractions were assayed and presented antiplasmodial activity, particularly against chloroquine-resistant Plasmodium falciparum (clone W2). |
| 申请人 |
UNIVERSIDADE FEDERAL DO PARÁ;UNIVERSIDADE FEDERAL DE MINAS GERAIS-UFMG;MUSEU PARAENSE EMÍLIO GOELDI;INSTITUTO EVANDRO CHAGAS;SECRETARIA EXECUTIVA DE SAÚDE PÚBLICA DO ESTADO DO |
发明人 |
DOLABELA, MARIA FÂNI;MARTINS, MICHEL T.;BRANDÃO, DAYSE LÚCIA DONASCIMENTO;BORGES, EDINILZA DA SILVA;PERCÁRIO, SANDRO;MARINHO, ANDREY MOACIR DO R.;SILVA, THIAGO L. DA;VILHENA, THYAGO DA COSTA;VASCONCELOS, FLÁVIO DE;MOTA, EDUARDO F.;SILVA, ADRIANA VEIGA DA CONCEIÇÃO;OLIVEIRA, ALAÍDE BRAGA DE;BRANDÃO, GERALDO CÉLIO;PAULA, RENATA CRISTINA DE;NASCIMENTO, MARIA FERNANDA ALVES DO;PÓVOA, MARINETE MARINS;COELHO-FERREIRA, MARLIA REGINA;BUSMAN, DÂMARIS |
