| 摘要 |
Preparing a pharmaceutical intermediate, comprising mixing (a1) sildenafil base, (b1) wicking agent, (c1) disintegrant, and (d1) optionally plasticizing agent, compacting the mixture, and crushing the compacts. Independent claims are included for: (1) preparing a melt tablet containing the component (a1), comprising preparing the intermediate, mixing the intermediate with other pharmaceutical excipients, and compressing the mixture; (2) the intermediate obtained by the process; and (3) melt tablet obtained by the above process. ACTIVITY : Vasotropic. MECHANISM OF ACTION : Cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor. |
