发明名称 |
Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
摘要 |
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. |
申请公布号 |
US9271968(B2) |
申请公布日期 |
2016.03.01 |
申请号 |
US201414262612 |
申请日期 |
2014.04.25 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
Viscomi Giuseppe Claudio;Campana Manuela;Confortini Donatella;Barbanti Maria;Braga Dario |
分类号 |
A61K31/395;A61K31/437;C07D498/22 |
主分类号 |
A61K31/395 |
代理机构 |
Steinfl & Bruno LLP |
代理人 |
Steinfl & Bruno LLP |
主权项 |
1. A pharmaceutical composition comprising a therapeutically effective amount of rifaximin together with excipients, wherein the rifaximin has a X-ray powder diffraction pattern peaks at about 5.7°±0.2, 6.7°±0.2 and 8.0°±0.2. |
地址 |
IT |