| 发明名称 | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases | ||
| 摘要 | The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies. | ||
| 申请公布号 | US9273302(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201414454310 | 申请日期 | 2014.08.07 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Chiang Kyle P.;Gardiner Elisabeth;Lau Ching-Fun;Lo Wing-Sze;Greve Jeffrey;Ashlock Melissa;Mendlein John D. |
| 分类号 | A61K38/00;C07K1/00;A61K38/17;C12N9/00;A61K38/16;A61K48/00;A61K38/53;G01N33/573 | 主分类号 | A61K38/00 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. An aseptic immunoadsorbent composition, comprising a biocompatible solid support having attached thereto at least one histidyl-tRNA synthetase (HRS) polypeptide of 500-506 amino acids in length that is least 90% identical to SEQ ID NO:70 (HRS(1-506)) and lacks residues 507-509 of SEQ ID NO:1, wherein the HRS polypeptide has reduced interchain disulfide formation under reducing conditions relative to the polypeptide of SEQ ID NO:1 (full-length HRS). | ||
| 地址 | San Diego CA US | ||