| 主权项 |
1. An implant comprising:
a porous layer comprising collagen, a first hydrogel precursor; a second hydrogel precursor layer containing a second hydrogel precursor, optionally a non porous layer comprising collagen, wherein the first hydrogel precursor is present in a layer selected from said porous layer and said non porous layer, and the second hydrogel precursor layer defines a coating on at least one layer selected from said porous layer and said non porous layer, the coating defining a non-uniform film pattern selected from stripes, pellets, peripheral outlines, and combinations thereof, wherein the first and second hydrogel precursors are maintained in their respective layers separate from each other until the implant is placed at a site of implantation and exposed to physiological fluids thereby reacting the first and second hydrogel precursors with each other to form a self-sticking biocompatible cross-linked material which sticks the implant to tissue at the site of implantation. |
