| 发明名称 | <i>Francisella tularensis </i>live vaccine strains and methods of use | ||
| 摘要 | The present invention includes live strain of Francisella tularensis wherein a gene selected from the group consisting of priA and purA is inactivated. The present invention further includes a pharmaceutical composition comprising one or more live strains of Francisella tularensis according to the present invention and a pharmaceutically acceptable carrier. The present invention further includes a method of using one or more live strains of Francisella tularensis according to the present invention to confer immunity against a virulent strain of Francisella tularensis. The method comprises administering an effective amount of one or more live strains of Francisella tularensis according to the present invention or a pharmaceutical composition comprising one or more live Francisella tularensis strains to an animal such that an immune response is produced in the animal. | ||
| 申请公布号 | US9272027(B1) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201414480071 | 申请日期 | 2014.09.08 |
| 申请人 | The United States of America as represented by the Secretary of the Air Force | 发明人 | Lamkin Thomas J;Saldanha Roland |
| 分类号 | A61K39/02;A61K49/00;A61K48/00;C12N15/74;A61K39/00 | 主分类号 | A61K39/02 |
| 代理机构 | AFMCLO/JAZ | 代理人 | AFMCLO/JAZ ;Whitaker Chastity |
| 主权项 | 1. A live strain of Francisella tularensis Schu4, wherein a gene selected from the group consisting of priA and purA is inactivated. | ||
| 地址 | Washington DC US | ||