Systems and methods for genetic and biological analysis

摘要

The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.

主权项

1. A system for detecting a biological molecule or a biological reaction associated with said biological molecule, comprising:
a bead in a solution and having attached thereto a biological molecule; a pair of electrodes in contact with said solution and positioned within the Debye layer of said bead; and a bead capture feature that immobilizes said bead, in proximity to said pair of electrodes, wherein, during use, said pair of electrodes and said bead provide an electrical current flow path for the generation of a signal useful for detecting said biological molecule or said biological reaction in said solution.